Nkhani - Wakupha Wobisika ku Canine WorldMalignant Hyperthermia

Eni ake a ziweto ayenera kuti adamvapo za canine malignant hyperthermia - matenda oopsa a cholowa omwe nthawi zambiri amapezeka mwadzidzidzi pambuyo pa opaleshoni. M'malo mwake, imagwirizana kwambiri ndi zovuta zomwe zimachitika m'thupiMtengo wa RYR1,ndikuyesa kwa nucleic acidndiye mfungulo yodziwiratu ngozi ya majini imeneyi.

Pankhani ya cholowa chake, mgwirizano wa sayansi ndikuti umatsatiracholowa chachikulu cha autosomal chokhala ndi malowedwe osakwanira-kutanthauza kuti agalu onyamula jini yosinthika sangawonetse zizindikiro nthawi zonse; kuwonetseredwa kumadalira zoyambitsa zakunja ndi milingo ya jini.

Lero, tiyeni tiwuze mozama momwe matendawa amachitikira pansi pa chibadwa ichi komanso zomwe zimayambitsa.

Chinsinsi Kumbuyo kwa RYR1 Gene Kutuluka Mwaulamuliro

Kuti timvetsetse njira ya canine malignant hyperthermia, choyamba tiyenera kudziwa "ntchito ya tsiku" ya jini ya RYR1 - imakhala ngati "woyang'anira zipata za calciumM'mikhalidwe yabwino, galu akamasuntha kapena akufunika kugundana kwa minofu, njira yoyendetsedwa ndi jini ya RYR1 imatseguka, ndikutulutsa ayoni a calcium osungidwa mu ulusi wa minofu kuti ayambitse kugundana.

ndondomeko yonse imakhala yadongosolo komanso yoyendetsedwa bwino, popanda kutulutsa kutentha kwakukulu.

Komabe, pamene jini ya RYR1 imasintha (ndipo cholowa chodziwika bwino cha autosomal chimatanthauza kuti kopi imodzi yosinthika ikhoza kukhala ya pathogenic), "woyang'anira pakhomo" uyu amalephera kulamulira. Imakhala yovutirapo kwambiri ndipo imakonda kukhala yotseguka pansi pa zokopa zina, zomwe zimapangitsa kuti ayoni ambiri a calcium asefukire mosaletseka mumitsempha.

Panthawiyi, maselo a minofu amagwera mumkhalidwe wa "chisangalalo chambiriIzi zimawononga mphamvu mwachangu ndipo zimatulutsa kutentha kwakukulu. Kusalinganika kumayambitsa mavuto ambiri: kagayidwe kake kamene kamayambitsa lactic acid ndi creatine kinase, yomwe imadziunjikira m'magazi ndi kuwononga ziwalo monga impso (creatine kinase ikhoza kutseka ma tubules a aimpso) ndi chiwindi, mitsempha ya minofu imatha kuphulika pansi pa kugwedezeka kosalekeza, kuchititsa rhabdomyolysis, kupweteka kwa mkodzo, kupweteka kwa mkodzo, mdima wandiweyani, mdima wandiweyani. Matenda owopsa amatha kukhala ndi arrhythmia, hypotension, kupuma mwachangu, komanso kulephera kwa ziwalo zambiri-popanda kuchitapo kanthu mwadzidzidzi, chiwopsezo cha kufa chimakhala chokwera kwambiri.

Apa tiyenera kutsindika kusakwanira kulowa: agalu ena amanyamula masinthidwe a RYR1 koma samawonetsa zizindikiro m'moyo watsiku ndi tsiku chifukwa mafotokozedwe a jini amafunikira choyambitsa. Pokhapokha pamene zosonkhezera zina zachitika m’pamene kusinthako kumayamba kugwira ntchito ndipo ngalande za kashiamu zimalephera kulamulira. Izi zikufotokozera chifukwa chake onyamula ambiri amakhalabe athanzi kwa moyo wonse ngati samakumana ndi zoyambitsa-koma amatha kuyambika mwadzidzidzi atayambika.

Zitatu Zazikulu Zoyambitsa Canine Malignant Hyperthermi

Zomwe zafotokozedwa pamwambapa nthawi zambiri zimayambitsidwa ndi magulu atatu azinthu:

1. Specific Anesthetic Agents (Choyambitsa Choyambitsa)Choyambitsa champhamvu kwambiri chimaphatikizapo mankhwala ena ogonetsa—mongahalothane, isoflurane, sevoflurane, ndi depolarizing minofu relaxants ngati succinylcholine. Mankhwalawa amalumikizana mwachindunji ndi jini yosinthika ya RYR1, kupititsa patsogolo njira za calcium. Deta yachipatala imasonyeza kuti pafupifupi 70% ya milandu ya canine yoopsa kwambiri ya hyperthermia imachitika panthawi ya opaleshoni pogwiritsa ntchito mankhwala osokoneza bongo, nthawi zambiri mkati mwa mphindi 10-30 pambuyo pa kulowetsa.

2. Kutentha Kwachilengedwe ndi Ntchito ZathupiKutentha kwambiri ndi chinyezi (monga magalimoto otsekedwa otentha, makonde a dzuwa) amachepetsa kutentha. Ngati galu akugwira ntchito mwamphamvu pansi pazimenezi, kutentha kwa metabolic kumawonjezeka kwambiri. Kuphatikizidwa ndi zolakwika za RYR1, izi zitha kuyambitsa jini yosinthika. Milandu idanenedwanso pamayendedwe chifukwa cha kutentha, kupsinjika, komanso kuyenda pang'ono.

3. Kuyankha Kwambiri Kupsinjika MaganizoKuvulala kwa opaleshoni, mantha odzidzimutsa (mwachitsanzo, kuthamangitsidwa ndi nyama yaikulu, zowombera mokweza), kapena kupweteka kwambiri (kuthyoka, kuvulala) kungayambitse adrenaline ndi mahomoni ena opsinjika maganizo. Mahomoniwa amayambitsa jini yosinthika ya RYR1 molakwika, zomwe zimapangitsa kuti calcium itulutsidwe molakwika. Labrador yonyamula masinthidwe nthawi ina inayambitsa hyperthermia yoopsa chifukwa cha kupsinjika maganizo kwa ngozi ya galimoto-chitsanzo cha kulowa kosakwanira komwe kumayambitsidwa ndi zokopa zakunja.

Ndikofunikira kudziwa kuti matendawa amatha kusiyanasiyana kutengera mtundu.Labrador Retrievers, Golden Retrievers, Beagles, Vizslas, ndi mitundu ina ili ndi kuchuluka kwa masinthidwe a RYR1, pomwe mitundu yaying'ono ngati Chihuahuas ndi Pomeranians ili ndi milandu yocheperako. Zaka zimagwiranso ntchito - agalu ang'onoang'ono (wazaka 1-3) amakhala ndi minofu yambiri yogwira ntchito, zomwe zimawapangitsa kukhala pachiopsezo choyambitsa matenda kuposa agalu akuluakulu.

Kuyeza Ma Genetic: Kupewa Zizindikiro Zisanawonekere

Kwa eni ziweto, kumvetsetsa njira ndi zoyambitsa izi zimathandiza kupewa bwino:

Ngati galu wanu ndi amtundu wowopsakapena alimbiri ya banja(cholowa chachikulu chimatanthawuza kuti achibale atha kukhala ndi masinthidwe omwewo), nthawi zonse dziwitsani veterinarian pamaso pa opaleshoni. Atha kusankha mankhwala otetezeka (mwachitsanzo, propofol, diazepam) ndikukonzekera zida zoziziritsira (mapaketi oundana, zofunda zoziziritsira) ndi mankhwala odzidzimutsa.

Pewanikuchita masewera olimbitsa thupi kwambirinthawi yotentha.

Chepetsanikupsinjika kwakukulukuchepetsa kuwonekera koyambitsa.

Mtengo wa kuyesa kwa nucleic acidchifukwa canine malignant hyperthermia yagona pakuzindikira ngati galu wanu ali ndi kusintha kwa RYR1. Mosiyana ndi kuyezetsa ma virus, komwe kumazindikira matenda, kuyesa kotereku kumawonetsa kuopsa kwa majini. Ngakhale galu atakhala kuti alibe zizindikiro chifukwa cha kulowetsa kosakwanira, kudziwa momwe chibadwa chake chimakhalira kumathandiza eni ake kusintha chisamaliro ndi zisankho zachipatala kuti apewe zoyambitsa-kuteteza ziweto ku moyo wowopsawu.

Nthawi yotumiza: Nov-13-2025

Wakupha Wobisika mu Canine WorldMalignant Hyperthermia