Gawo la Gawo la China pa China Woyamba Pakamwa pa Nejm Show Volication Osati Kupanda Paxlovid

M'mawa koyambirira kwa 29 December, Nejm adasindikizidwa pa intaneti kukhala kuphunzira kwatsopano kwa chipatala chatsopano cha China vv116. Zotsatira zake zidawonetsa kuti VV116 sinali yoyipa kuposa paxlovid (nematovir / ritonavir) malinga ndi nthawi yachipatala ndipo anali ndi zochitika zochepa.

GAWO LAKUDYA: Nejm

Nthawi yochiritsika masiku 4, nyengo yovuta 67.4%

VV116 ndi ma ecleositode anti-coronavirus (SARS-Cov-2)

Mu 2021, gawo la gawo lachipatala la VV116 lidamalizidwa ku Uzbekistan. Zotsatira za phunziroli zinawonetsa kuti gulu la VV116 likhoza kusintha zizindikiro zamankhwala mozama mawonekedwe a mawonekedwe ndi imfa poyerekeza ndi gulu lotsutsa. Kutengera ndi zotsatira zabwino za mlanduwu, vv116 yavomerezedwa ku Uzbekistan yothandizira odwala omwe ali ndi covid wolimbitsa thupi kwambiri-19, ndipo wakhala woyamba wa mankhwala atsopano ovomerezeka ku China [1].

Gawoli la gawoli lachipatala. Kuwunika kwamphamvu ndi chitetezo cha vv116 motsutsana ndi Paxlovid paxlovid yoyambirira kulandira odwala omwe ali ndi mwayi wokhala ndi covid-19. Cholinga chake chinali kupenda kufunikira ndi chitetezo cha vv116 motsutsana ndi Paxlovid paxlovid pomwe amathandizira odwala omwe ali ndi mwayi wokhala ndi Covid-19.

Gwero lazithunzi:

Ambiri, owona, achititsidwa khungu, osokonezeka, opezeka pa 8 Epulo ndi 2 Meyi 2022 kuti ayesetse kumbali ya zipatala zisanu ndi ziwiri ku Shanghai, China. Pamapeto pake, otenga nawo mbali adalandira VV116 (384, 600 mg pa tsiku 1 mpaka 300) kapena 300 mg ritonavir maola 5) ngati mankhwala amkambo.

Zotsatira za phunziroli kuchipatala ichi zidawonetsa kuti chithandizo choyambirira ndi vv116 chofatsa kwambiri ku Covid-19 Pamapeto Omaliza (Nthawi Yachipatala, 1.8).

Kusungabe nthawi yachipatala

Mapeto ang'ono komanso a sekondale (kusanthula kwathunthu kwa anthu)

Gwero lazithunzi:

Potengera chitetezo, ophunzira kulandira VV116 adanenanso za zochitika zochepa (67.4%) kuposa omwe amalandila paxlovid (77.3%) pazinthu zitatu, komanso zomwe zidali ndi zochitika za Paxlovid (5.7%).

Zochitika zoyipa (anthu otetezeka)

Gwero lazithunzi:

Mikangano ndi mafunso

Pa Meyi 23, 2022, Juniper adawulula kuti njira zamankhwala a vv116 motsutsana ndi Paxlovid yoyambirira mankhwala ofatsa kwa covid-19 (nct05344609) idakumana ndi nthawi yake yoyamba kuphunzira.

Gwero lazithunzi:

Pakadali zambiri za mayeserowo anali kusowa, mkangano woyandikana ndi Phunziro la gawo la III chinali awiriwo ndipo, popeza anali kufufuza kwa malo olamulira, kunali kovuta kuweruza mankhwala molondola; Kachiwiri, panali mafunso okhudza maphunziro azachipatala.

Njira yokhazikika ya Juniper ndi zotsatira zabwino zamayeso atsopano, (II) yofatsa kapena yofananira kapena yocheperako-19, ndipo (iii) odwala omwe ali pachiwopsezo chachikulu cha Covid-19, kuphatikizapo imfa. Komabe, malo omaliza okha azachipatala ndi nthawi yopuma '.

Asanalengezedwe, pa Meyi 14, Juniper anali atakonzanso mbali yazachipatala pochotsa mbali ina ya chipatala, "kuchuluka kwa kutembenukira kumatenda kapena kufa" [3].

Gwero lazithunzi:

Msagoge ziwirizi za mkangano zidayankhulidwadi mu kafukufukuyu.

Chifukwa cha kuwonongeka kwadzidzidzi kwa malovu a malo a Paxlovid sikunathere asanayesedwe chifukwa chifukwa chake ofufuza sanathe kuchititsa kuti vutoli lipangidwe kawirikawiri. Ponena za mbali imodzi yakhungu yamayesero azachipatala, juniper inanena kuti protocol inkachitika pambuyo polumikizana ndi ophunzirira mankhwalawa (kuphatikizapo kuwunika komaliza komwe kumatha kumapeto kwa kafukufukuyu.

Kufikira nthawi yomaliza, palibe aliyense mwa omwe anali atazengedwa mlandu wina yemwe anali atamwalira kapena kukafika pa chochitika chachikulu cha Covid. Zambiri zidawonetsa kuti nthawi yomwe yatsala pang'ono kusinthidwa kuti ikhale yosinthika ya zizindikiro za Covid-19 (95% CI, 7 mpaka 8) m'magulu awiri (95% CI, 0.91) [2). Palibe zovuta kufotokoza chifukwa chake 'kutembenuka mtima kwa kutembenuka mtima kwa matenda oopsa kapena kufa', komwe kumayambiriro kwa mayeserowo asanathe.

Pa 18 Meyi 2022, uthengawo umatulutsa ma virus & matenda omwe adasindikiza zotsatira za kuyesa kwa VV116 kwa odwala omwe ali ndi vonalror.

Zambiri kuchokera paphunziroli zidawonetsa kuti odwala omwe amagwiritsa ntchito vocticron masiku 5 a mayeso a acid ndi masiku 5,50, ochepera m'magulu a gulu lowongolera. Kuyang'anira kwa vv116 ku matenda omwe ali mkati mwa kafukufukuyu (masiku 2-10 a mayeso oyamba anyukiliya) adachepetsa nthawi yodziwika bwino kwa odwala onse. Pankhani ya chitetezo cha mankhwala, palibe zovuta zazikulu zomwe zidawonedwa mu The Vv116 Chithandizo.

GAWO LOSAVUTA:

Pali ziyeso zitatu zopitilira zomwe zapitilira pa vv116, ziwiri zomwe zimakhala maphunziro a gawo lofatsa kwa ofatsa ku Covid-19 (Nct052242042, NCT05582629). Kuyesedwa kwina kwa covid kwambiri mpaka 19 ndi kafukufuku wapadziko lonse lapansi, kafukufuku wakhungu kwambiri. Malinga ndi chilengezo cha Juniper, wodwala woyamba adalembetsa ndikulemba mu Marichi 2022.

Gwero: Zachipatala.Siltrial.gov

Zolemba:

[1] Junshi Biotech: Kulengeza pamalo omaliza a Puse III Kulembetsa Kusintha kwa Viv116 motsutsana ndi Paxlovid Poyambirira Kuchizira Covid-19

[2] https://www.nejg.org/mogl/10.1056/hvmoo22322601609. Jianming Zheng, Xiagang Gao, Juo, Hiren Fu, Helin hin, Heling hin, Zesing Zhang, Zengxin Lang. . Akutuluka tizilombo tating'onoting'ono komanso matenda 11: 1, masamba 2636-2644.