Odwala khansa ya m'mapapo, kodi kuyezetsa kwa MRD ndikofunikira?

MRD (Minimal Residual Disease), kapena Minimal Residual Disease, ndi chiwerengero chochepa cha maselo a khansa (maselo a khansa omwe samayankha kapena osagwirizana ndi chithandizo) omwe amakhalabe m'thupi pambuyo pochiza khansa.
MRD ikhoza kugwiritsidwa ntchito ngati biomarker, ndi zotsatira zabwino zomwe zikutanthauza kuti zotsalira zotsalira zimatha kuzindikirika pambuyo pa chithandizo cha khansa (maselo a khansa amapezeka, ndipo maselo otsala a khansa amatha kukhala amphamvu ndikuyamba kuchulukira pambuyo pa chithandizo cha khansa, zomwe zimayambitsa kuyambiranso kwa khansa. matenda), pamene zotsatira zoipa zikutanthauza kuti zotsalira zotsalira sizidziwike pambuyo pa chithandizo cha khansa (palibe maselo a khansa omwe amapezeka);
Ndizodziwika bwino kuti kuyezetsa kwa MRD kumatenga gawo lofunikira pozindikira odwala omwe ali ndi khansa ya m'mapapo omwe si aang'ono (NSCLC) omwe ali pachiwopsezo choyambiranso komanso kutsogolera chithandizo chamankhwala pambuyo pa opaleshoni yoopsa.
Zochitika zomwe MRD ingagwiritsidwe ntchito:

Kwa opaleshoni yoyambirira khansa ya m'mapapo

1. Pambuyo pa kuchotsedwa kwakukulu kwa odwala khansa ya m'mapapo omwe sanali ang'onoang'ono, MRD positivity imasonyeza kuti pali chiopsezo chachikulu cha kuyambiranso ndipo kumafuna kuyang'anira mosamala. Kuwunika kwa MRD kumalimbikitsidwa miyezi 3-6 iliyonse;
2. Ndibwino kuti tiyesetse kuyesa kansa ya m'mapapo yosakhala yaing'ono ya m'mapapo yotengera MRD, ndikupereka njira zochiritsira zolondola kwambiri momwe zingathere;
3. Limbikitsani kufufuza ntchito ya MRD mu mitundu yonse ya odwala, jini yoyendetsa galimoto ndi jini yoyendetsa galimoto, mosiyana.

Kwa khansa ya m'mapapo yomwe si yaing'ono kwambiri

Kuyezetsa kwa 1.MRD kumalimbikitsidwa kwa odwala omwe ali ndi chikhululukiro chathunthu pambuyo pa mankhwala amphamvu kwambiri a khansa ya m'mapapo yomwe si yaing'ono ya m'mapapo, yomwe ingathandize kudziwa zomwe zikuchitika ndikupanga njira zina zothandizira;
2. Mayesero achipatala a MRD-based consolidation therapy pambuyo pa chemoradiotherapy akulimbikitsidwa kuti apereke njira zochiritsira zogwirizanitsa bwino momwe zingathere.
Kwa khansa ya m'mapapo yomwe si yaing'ono yama cell
1. Pali kusowa kwa maphunziro ofunikira pa MRD mu khansa ya m'mapapo yosakhala yaying'ono;
2. Ndibwino kuti MRD ipezeke kwa odwala mwachikhululukiro chathunthu pambuyo pa chithandizo chamankhwala chapamwamba cha khansa ya m'mapapo yopanda maselo ang'onoang'ono, omwe angathandize kuweruza matendawa ndikupanga njira zowonjezera zothandizira;
3. Ndibwino kuti tichite kafukufuku pa njira zochiritsira za MRD kwa odwala mwachikhululukiro chokwanira kuti atalikitse nthawi ya chikhululukiro chonse momwe angathere kuti odwala athe kupindula kwambiri.

Zitha kuwoneka kuti chifukwa cha kusowa kwa maphunziro ofunikira pakuzindikiritsa kwa MRD mu khansa ya m'mapapo yosakhala yaying'ono, kugwiritsa ntchito kuzindikira kwa MRD pochiza odwala omwe si ang'onoang'ono a khansa ya m'mapapo sikunawonetsedwe bwino.
M'zaka zaposachedwa, kupita patsogolo kwamankhwala omwe akuwunikiridwa komanso chitetezo chamthupi kwasintha mawonekedwe a chithandizo kwa odwala omwe ali ndi NSCLC yapamwamba.
Umboni womwe ukubwera ukuwonetsa kuti odwala ena amapeza moyo wautali ndipo amayembekezeredwa kuti akhululukidwe kwathunthu pojambula. Choncho, poganizira kuti magulu ena a odwala omwe ali ndi NSCLC yapamwamba azindikira pang'onopang'ono cholinga chokhala ndi moyo wautali, kuyang'anira kuyambiranso kwa matenda kwakhala vuto lalikulu lachipatala, ndipo ngati kuyezetsa kwa MRD kungathenso kukhala ndi gawo lofunika kwambiri pakuyenera kufufuzidwa. m'mayesero ena azachipatala.